Sucrose polyester in human volunteers — reply by Kelly & Hunter

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Sucrose polyester in human volunteers.

The recent publication by Kelly et al. (1998) of their study on sucrose polyesters (SPE) raised concerns about the possible gastrointestinal (GI) and nutritional effects of olestra. These concerns were echoed in the popular press (‘Doubts raised over anti-obesity fat substitute’. The Times, 11 August 1998.). Olestra’s potential to cause GI and nutritional effects has been carefully reviewed by ...

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A 3-month, double-blind, controlled trial of feeding with sucrose polyester in human volunteers.

Sucrose polyester (SPE) is a tasteless, odourless substance which reduces plasma cholesterol concentrations and may therefore be valuable as a fat substitute in human foodstuffs. It has recently been approved for use in snack foods by the United States Federal Drug Administration. The current study was designed to investigate its effects on gastrointestinal physiology and nutrient absorption in...

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Reply to Kelly et al

REPLY: We thank Kelly and coworkers (3) for their comments. We agree that some of the Ren-2 animals in our study did develop malignant hypertension, as discussed in our report (see the penultimate paragraph of the DISCUSSION in Ref. 1). We included all animals which survived to the end of the study in the final analysis because we feel that the exclusion of animals with malignant hypertension w...

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A Second Reply to Hunter

In O(3) symmetry electrodynamics the field tensor is governed by a nonAbelian Stokes Theorem, as in any non-Abelian gauge theory. The comments on the B component of this field tensor by Hunter in this Issue address B as if it were a U(1) symmetry field, governed by the ordinary Stokes Theorem, and are therefore sequentially erroneous, because there is a basic misunderstanding of the nature of O...

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Reply to Sullivan and Kelly and Skowronski et al.

TO THE EDITOR—We appreciate the in-sightful comments of Sullivan and Kelly and Skowronski et al concerning our article on influenza vaccine effectiveness in households during the 2010–2011 season. The comments of Sullivan and Kelly overall confirm, in another setting and influenza season (2012), that past vaccination may have a negative effect on current season vaccine effectiveness (VE). They ...

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ژورنال

عنوان ژورنال: British Journal of Nutrition

سال: 1999

ISSN: 0007-1145,1475-2662

DOI: 10.1017/s000711459900032x